This work is an assessment of the indigenous leather tanning in Nigeria. It documents the applicable technology and the knowledge base supporting the technology. The study also explores mode of knowledge transmission in the industry, the extent of government intervention and factors militating against the industry. It was discovered that the mode of knowledge transmission in leather tanning is informal as learners take oral instruction, and capability is acquired through practice; and that the knowledge system around leather tanning has evolved to become much more systematic, with advanced supporting technologies. The project recommends that (i) leather tanning procedures be documented, especially in the local language; (ii) the practitioners of leather tanning should be given formal education on their profession; (iii) micro-credit facility be provided for these practitioners; (iv) leather tanning practitioners should be encouraged to interact with National Research Institute for Chemical Technology (NARICT) and the Federal College of Chemical and Leather Technology (CHELTECH); (v) leather tanning and other indigenous technologies should be included in school curriculum in the various localities where they are prevalent.